Rectal cancer nice guidelines

Rectal cancer on x ray, Rectal cancer x ray - Cancer prevention through screening programs

The nucleocrine pathway comes of age Razvan T. Radulescu More than 20 years ago, it was initially predicted that hormones and growth factors might promote cell growth by binding and thereby inactivating tumor suppressors, as exemplified by the proposed complex formation between insulin and retinoblastoma protein RB. Meanwhile, additional nucleocrine pairs have emerged through further experimental studies, specifically the FGF1-p53 and angiogenin-p53 heterodimers. Moreover, first experimental clues have been obtained as to the intranuclear presence of the previously surmised heterodimer between the EGF precursor and the p tumor suppressor.

These findings point to a more general significance of the nucleocrine pathway in cell growth regulation and as a particularly useful target in cancer therapy.

Carbon nanotubes for cancer therapy and neurodegenerative diseases Elena Daniela Melita, Gabriela Purcel, Alexandru Mihai Grumezescu Our review summarizes the latest approaches regarding a new class of nanomaterials - carbon nanotubes CNTs - which are promising candidates in different areas of nanomedicine.

This paper discusses the main applications of CNTs in the repair of injured nerves and also as delivery systems for cancer therapy in difficult to reach anatomic sites.

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In terms of neurological applications, we focus on neural interface, neural stimulation, microelectrodes, and differentiation of stem cell into neural cells. Also, we highlight the in vitro and in vivo applications of CNTs-mediated cancer therapy and we will explain why CNTs are used for the treatment of difficult tumors.

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Corresponding author: Alexandru Mihai Grumezescu, Chem. The study group included 52 patients diagnosed with hepatic metastases. The obtained data demonstrate that HMNPs can be used as an efficient drug delivery system, for clinically relevant antimicrobial drugs. HMNPs antimicrobial activity depended on the loaded drug structure and the tested microbial strain, being more efficient against Pseudomonas aeruginosa, comparing with the Escherichia coli strain.

The novel HMNPs demonstrated an acceptable biocompatibility level, being thus a very good candidate for biomedical applications, such as drug delivery or targeting. Corresponding author: Dan Eduard Mihaiescu, Chem.

Ultrastructure of the human palatine tonsil and its functional significance Marko Jovic, Verica Avramovic, Predrag Vlahovic, Vojin Savic, Aleksandra Velickov, Vladimir Petrovic The human palatine tonsils represent a mucosa-associated lymphoid tissue with a significant function in mucosal protection against alimentary and airborne pathogens. The ultrastructure of different morphological compartments in the human palatine tonsil was studied in eighteen tonsils obtained from the patients who had undergone elective tonsillectomy due to chronic tonsillitis.

The tonsillar specimens were analyzed by scanning and transmission electron microscopy.

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The results showed the presence of tight junctions between superficial epithelial cells of the oropharyngeal tonsillar surface. Antigen-presenting Langerhans cells with typical intracytoplasmic Birbeck granules were also found in the crypt epithelium.

The lymphoid follicles are composed of lymphocytes and two types of non-lymphoid follicular cells: small fibroblast-like cells and large cells, morphologically consistent with antigen-bearing follicular dendritic cells or macrophages.

The interfollicular areas consisted of a dense network of reticular cells and reticular fibers; many lymphocytes were interspersed between the reticular fibers. In addition to arterioles and high endothelial venules in the interfollicular lymphoid tissue, some fenestrated capillaries were seen intraepithelially and subepithelially.

The complex ultrastructure of the human palatine tonsil provides a microenvironment necessary for antigen uptake, antigen processing and immune response. Corresponding author: Marko Jovic; e-mail: marko. BRCA1 insC founder mutation has not a significative recurrent presence in Northeastern Romanian cancer patients Lucian Negura, Cristian Petru Dusa, Miruna Ioana Balmus, Doina Azoicai, Anca Mihaela Negura, Mihai Vasile Marinca, Lucian Miron Developed two decades ago, oncogenetic rectal cancer on x ray practice mainly concern breast, ovarian and colorectal cancers, and is targeting the hereditary risk factor, the only one that shows positive predictive value justifying the molecular diagnosis.

The gold standard for molecular diagnosis is Sanger sequencing of all exons and exon-intron boundaries, which is expensive and time consuming. More than BRCA sequence variants are reported in international databases, rectal cancer on x ray in some populations or ethnic groups a few founder mutations showed to have a recurrent presence. This may be very useful in establishing a combined technical approach for mutation detection, including rapid and cheap pre-screening methods for most common mutations.

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Here we present a complete screening of consecutive series of breast and ovarian cancer patients for the presence rectal cancer on x ray BRCA1 insC. The presence of the mutation was investigated by allele specific multiplex-PCR on genomic DNA extracted from peripheral blood. No mutation carrier was identified among breast or ovarian cancer patients. Our findings suggest that BRCA1 insC may not have a strong recurrent effect in Romanian population comparing to neighboring countries.

This may be particularly useful in establishing further pre-screening strategies. The study group consisted of 61 individuals with MS and the control group of 73 individuals without MS, matched for age and gender. For each individual, clinical and genetic parameters with possible influence on PON1 activities paraoxonase, medicamente parazitare cu spectru larg pentru copii and lactonase were measured.

PON1 activities were influenced by all three polymorphisms, regardless of the presence of MS. Sonographic evaluation of fetal cerebral structures correlated with histological aspects Alexandru Cristian Comanescu, Nicolae Cernea, Oana-Sorina Tica, Maria Victoria Comanescu, Elena Carmen Niculescu, Charoula Florou, Florin Grosu Prenatal development of the human brain from undifferentiated neuroepithelium, crosses numerous steps towards primordial organization and subsequent cytoarchitectural layering, ascending and progressive from the lower cortical layers to the superior ones.

Our study represents a systematic, comparative assessment of imaging studies and the histological evaluation of the prenatal development of the human brain.

We evaluated cases using 3D ultrasound.

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Histological study was performed on 17 cases aged between 8 and 32 weeks pregnancy and compared with imaging results. For the ultrasound study, we chose five anatomical landmarks: the choroid rectal cancer on x ray, thalamus, cerebellum, hippocampus and island Sylvian fissure.

The histological study was performed on dissected brain specimens preserved in formaldehyde and was followed by immunohistochemical determination in order to complete the picture of the morphological evolution of the structures evaluated. We analyzed the accuracy of the description of marker elements choroid plexus, thalamus, cerebellum, hippocampus and Sylvian fissure in three-dimensional ultrasound evaluation.

This showed a good correlation with the morphological evaluation as well as with the dimensional descriptions from the literature. Histological and immunohistochemical assessment helped complete the picture of the central nervous system development.

Highlighting fetal cerebral structures by three-dimensional ultrasound, together with morphological examination helped us create a dynamic array of the central nervous system development. Prognostic markers in the pathology of cardiac failure: echocardiography and autonomic nervous system dysfunction Elena Cristina Enciu, Silviu Marcel Stanciu, Dumitru Matei, Adrian Costache Introduction: Chronic heart failure is a major health problem worldwide and despite the therapeutic advances, the mortality and morbidity still remain high.

Echocardiography is the gold standard for left ventricular function assessment and may provide prognostic information for predicting future heart failure events. Patients and Methods: We analyzed the main echocardiographic markers used for the prognostic of chronic heart failure patients such as the ejection fraction, rectal cancer on x ray impairment and the collapse of inferior vena cava.

Also, another parameter is studied, recently recognized as a marker for future cardiac events: autonomic nervous dysfunction. The current paper makes a comprehensive approach of the echocardiographic markers recommended for the diagnosis and follow-up of heart failure adapted to what we really find in our everyday practice with a correct patient management in a clinical and biological context.

Even though left ventricle ejection fraction is the most often used parameter for cardiac failure follow-up and prognostic, new and more accurate parameters should be used: Tissue Doppler Imaging and Heart rate recovery - which may become a therapeutic target in the era of cardiac rehabilitation.

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Conclusions: There is no stand-alone marker for the assessment of cardiac failure; each of the parameters presented has its advantages and its pitfalls. Echocardiography allows a morphologic study, which should always be correlated with clinical and functional studies exercise stress test and autonomic nervous system dysfunction. Progressing as a chronic inflammation at the level of tooth support tissues, untreated chronic periodontitis may lead to a premature loss of the dental organ.

Even though the main lesions caused by the periodontal disease affect the alveolo-dental ligaments, we tried to highlight the presence of certain lesions of radicular dentine in patients with chronic marginal periodontopathy.

In our study, in the patients with chronic marginal periodontopathy, at periodontium level, there was highlighted the presence of a chronic inflammatory process with numerous lymphocytes and macrophages, microhemorrhages, and also areas with tissular necrosis.

At radicular dentine level, in the cases of old, untreated periodontal disease, there were observed areas of more or less extended demineralization, erosion and necrosis. Our study showed that chronic periodontal disease may affect the tooth, as well, not only its detoxifiere turcia tissues. Proximal tibial osteosarcoma in young patients: early diagnosis, modular reconstruction Razvan Ene, Ruxandra Diana Sinescu, Patricia Ene, Dan Popescu, Monica Mihaela Cirstoiu, Florin Catalin Cirstoiu Osteosarcoma is the most common bone tumor that occurs in children and young adults with prevalence of teenage.

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There can be identified many subtypes of osteosarcoma by how rectal cancer on x ray look on X-rays and under the microscope. Osteosarcoma can be classified as high-grade, intermediate grade, or low-grade. This has a significant prognostic value of tumor development suggesting the growth rate and the potential for expansion. Betweenin the Department of Orthopedics and Traumatology, University Emergency Hospital of Bucharest, Romania, were treated seven cases of osteosarcoma of the proximal third of the tibia in young, early-diagnosed cases without metastasis.

The treatment involved resection of tumor formation and reconstruction with a modular prosthesis. Postoperative patients were mobilized for a week without charging the operated limb under the protection of orthesis. During this period continued active and passive mobilization of the ankle and foot to prevent stiffness and to reduce postoperative swelling.

From the second postoperative week, patients are mobilizing with progressive charging but not being allowed to do any flexion in order to protect de insertion of medial gastrocnemius muscle rotation flap used to cover the prosthesis and to protect the patellar tendon reinsertion. This extensive surgery does not improve survival rate of these patients compared to treatment by amputation of this pathology but greatly increases the comfort of life and in all cases ensure socio-professional reintegration of these patients.

To ensure optimal postoperative results perform a complete diagnosis and preoperative oncological treatment before surgery, if applicable. One of the best known markers is CD34, a surface antigen. The most used immunohistochemical marker for identification of activated endothelial cells is CD We chose to compare these two markers in order to evaluate angiogenesis of the rectal cancers by determining the microvessel density MVD.

Our study included 31 patients with rectal cancer betweenwho underwent rectal resection at Arad and Timisoara Counties Hospitals, Romania. We used MVD quantification by highlighting the ajuta negii genitali blood vessels with two different endothelial markers using the immunohistochemical protocols.

The evaluation of both CDCD showed the role of angiogenesis in the cancer proliferation and local spread, the angiogenesis level being maintained high even in the advanced stages of the disease.

There was observed a difference between the intratumoral and peritumoral MVD, the study of this difference possibly leading to a better assessment of prognosis and adjusted therapies in the future. Immunohistochemical aspects of apoptosis in gingival mucosa with papilloma and condyloma acuminata Monica Scrieciu, Veronica Mercut, Razvan Mercut, Marina Olimpia Amarascu, Sanda Mihaela Popescu, Anca Mihaela Predescu, Ileana Monica Banita The oral mucosa is a component of the oral ecosystem, which can be aggressed by corrosion products released from the dental alloys used in prosthetic dentistry therapy.

About the colorectal cancer, prevention and risk factors, with Dr.

The purpose of this study was to compare the in vivo effect of nickel and copper compounds on the oral mucosa cells, including their ability to induce cell death, by analyzing the cytochrome c cyt. Gingival mucosa fragments obtained from the subjects with dentures manufactured by nickel or copper casting alloys were processed through the histological technique of paraffin inclusion.

The sections obtained were stained by usually histological methods in order to highlight the histopathological lesions and also analyzed using the immunohistochemical technique in order to study the cyt. The papillomatosis lesions were observed in the gingival mucosa fragments obtained from the subjects with nickel-based alloy împotriva viermilor milprazonici and the condyloma acuminata lesions were observed in those obtained from the subjects with copper-based alloy dentures.

The cyt. We can conclude that the two types of metal alloys have different effects on the adjacent gingival mucosa. The results of this study are indicating that the interaction between the HeLa cells and S. The pre-treatment of HeLa monolayer with inactivated bacterial cells 24 hours before the viral infection is increasing the expression level of TNF-alpha, Rectal cancer on x ray and IL-8 pro-inflammatory cytokines genes, also suggesting that bacterial antigens could contribute to the decrease of viral multiplication rate.

The current antiviral therapy allows the virus eradication or the permanent inhibition of the virus replication sustained virological response, SVRthe reduction of the inflammation, and the prevention or the reduction of liver fibrogenesis histological response. We studied the histopathological aspects found during percutaneous liver biopsy in patients with chronic hepatitis C viral infection who were treated and monitored over a period of two years.

The assessment of the histological activity index through Ishak score determined the presence of: mild chronic hepatitis in 12 The percutaneous liver biopsy performed on the patients with chronic viral hepatitis C showed a series of histological alterations, the most frequent being: portal inflammation, periportal necrosis, lobular inflammation, focal necrosis, and hepatic fibrosis scarring.

The severity degree of this histopathological aspect was correlated with the hepatitis activity index.

Account Options REVIEW-URI Contributions from international experts on specialized topics and various new illustrations ensure that the extensive rectal cancer vs fissure is not only current and authoritative, but easy to understand. No other book provides the expertise of a world-class editorial team with the cutting-edge knowledge you need to master colorectal surgery.

The association of piecemeal with bridging necrosis is the deadline at which the antiviral treatment can still be effective. Evidence of early fibrosis represent the important moment for the antiviral treatment start.

The specific histopathological aspects, but not pathognomonic, of chronic hepatitis C hepatic steatosis, rectal cancer on x ray lymphoid infiltrates and bile duct damage had a reduced incidence, occurring in only half hepatic steatosisa quarter portal lymphoid infiltrates and a fifth destruction of biliary ducts of all the patients with chronic viral hepatitis C, and these patterns was rectal cancer on x ray with advanced degree of necroinflammatory process of the liver, particularly in the portal tracts.

Fenugreek powder exerts protective effects on alcoholised rats kidney, highlighted using ultrastructural studies George Ciprian Pribac, Mircea Florin Sferdian, Carmen Neamtu, Constantin Craciun, Corina Luminita Rosioru, Aurel Ardelean, Bogdan Dan Totolici Trigonella foenum-graecum TFG seeds exert a protective antioxidant effect and membrane protector through their rich content in polyphenolic flavonoids. The previous research focused on the hypoglycemic action of the seeds, with scarce studies on the preventive effects in the pathology of the kidney.

Our work was conducted on rectal cancer on x ray experimental in vivo model; the animals were given two different concentrations of TFG seeds, consequently to alcohol intoxication. Transmission electron microscopy TEM analysis showed vacuolation in cytoplasm, edemas at the apical pole of the nephrocytes, diffusion of the cytoplasmic and mitochondrial matrix and the increase in number of the lysozymes and especially peroxisomes, as well as the congestion of blood capillaries.

In the case of the groups T5R and T10R, which received Trigonella powder together with ethanol, the structural and ultrastructural changes produced by the ethylic intoxication were more reduced, being somewhat improved in the T5R group. Therefore, the majority of the cells nuclei have retained their spherical shape, being at the same time predominantly euchromatic, with little heterochromatin and evenly dispersed.

Our results suggest the use of Trigonella seeds as a food supplement to prevent cellular deterioration and improve renal morphology and function. Considerations on morphological abnormalities of permanent teeth in children with cleft lip and palate Anca Maria Raducanu, Andreea Cristiana Didilescu, Ion-Victor Feraru, Mihaela Adina Dumitrache, Tudor Alexandru Hantoiu, Ecaterina Ionescu Oral clefts are commonly associated with dental anomalies of number, size, shape, structure, position and eruption affecting both dentitions.

Dental malformations may affect the development, growth and functions of the dento-maxillary apparatus chewing, aesthetics, speech. The study sample included 48 patients with various types of CLP 15 girls and 33 boys aged between The control group without CLP consisted of patients girls and boys. The proportion of patients with dental shape anomalies in the control group was 8.

We selected a group of 32 subjects 22 cases and 10 controls for studying the TNFA polymorphism and 97 subjects 66 cases and 31 controls for IL-1A polymorphism. The single nucleotide polymorphisms were genotyped by real-time polymerase chain reaction for all subjects.

The genotype and allelic distribution tended to be equally between the cases and the controls group. Similar results were obtained for the dominant and recessive model.

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This is the first such study for Romanian northeastern population. Materials rectal cancer on x ray Methods: A total of 33 odontogenic myxoma cases and three tooth germs were included. Immunohistochemistry was performed to localize VEGF-A and ORM-1 proteins in tumor cells, endothelial cells and extracellular matrix in the odontogenic myxomas.

Results: Immunopositivity was strong in the endothelial cells, which compose various vessels, and in the randomly oriented stellate, spindle-shaped and round tumoral cells with long cytoplasmic processes. ORM-1 expression was strong in both endothelial cells and tumor cells, and the myxoid extracellular matrix was positive, with moderate or strong immunoexpression in all cases. Conclusions: The results of this study suggest that the expression of VEGF-A and ORM-1 may be associated with two mechanisms angiogenesis and tumor structural viscosity that may influence tumor growth in odontogenic myxoma.

Our goal is the comparative examination of the expression of these markers in the digestive tract of week-old fetuses. Materials and Methods: We studied using immunohistochemical techniques esophagus, stomach, small and large intestine tissue samples collected from 18 post mortem fetuses of weeks.

EGFR expression appears only during the weeks period.

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The expression of p53 is strong until week 21, and then it is restricted to the deeper layers of the epithelium. Conclusions: Our findings suggest that these markers have role also in the fetal period and complete the scarce data found in literature about the expression of the studied markers in the development of the digestive tract.

Original Research ARTICLE

Interrelations between hepatic stellate cells and immune system cells in patients with hepatocellular carcinoma Alin Gabriel Ionescu, Sergiu Marian Cazacu, Costin Teodor Streba, Mircea Catalin Fortofoiu, Marius Eugen Ciurea, Mihaela Ionescu, Otilia Rogoveanu, Violeta Comanescu, Stefan George Firu, Cristin Constantin Vere Objective: Our aim was to identify potential correlations between activated hepatic stellate cells HSCs and immune system s cells in patients with viral C hepatocellular carcinoma, by quantifying the percentage of activated HSCs, T-lymphocytes, natural killer cells and B-lymphocytes, in three distinct regions: tumor, transition area and the vicinity tissue mm.

Patients and Methods: We prospectively included 20 samples prelevated at necropsy from patients with HCC and C viral infection. We found no correlation between the number of activated HSCs and the number of CDpositive cells in all three examined areas. Conclusions: The analysis of HSCs activity within specified areas of tumoral liver tissue may lead to new perspectives in early diagnosis of relapses and in the development of future neoadjuvant therapies.

Ultrasonography-histopathology correlation in major salivary glands lesions Cecilia Petrovan, Diana Maria Nekula, Simona Liliana Mocan, Toader Septimiu Voidazan, Adina Cosarca Major salivary glands display a various and complex pathology, showing different evolution and prognosis, depending on the histopathological form.

The choice of an appropriate treatment plan for the best outcome, therefore the proper surgical approach, would imply preoperative knowledge of the rectal cancer on x ray diagnosis. However, any virus papiloma tratamiento hombres performed prior to surgery presents the risk of a false result and increases the difficulty of latter surgery.

Therefore, some complementary examinations are used, among these, ultrasonography. The retrospective study April March conducted in the Clinic of Oral and Maxillofacial Surgery, Emergency County Hospital, Tirgu Mures, Romania, aims to evaluate the relevance of the ultrasonography by itself in leading towards a proper preoperative assessment and diagnosis, and thus, in choosing the proper treatment plan.

The study included 33 lesions of the major salivary glands, undergoing first ultrasonography, then curative surgery. Different characteristics shape, dimension, consistency, vascularization, homogeneity, delimitation were assessed on ultrasonography as well as on histopathology; finally, the correlation between those two examinations was evaluated, by comparing diagnoses.