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Cancer distension abdominal. Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian

The incidence of ovarian epithelial tumors varied across age groups, our study cancer distension abdominal including women aged between 34 and 64 years old.

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Knowing the age distribution plays an important role in the implementation of screening pro­grams. All cases presented with similar symptomatology: pelvic pain, cancer distension abdominal distension and ascites.

Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian The gross appearance of these tumors was overlapping in different histological subtypes, showing variable cystic and solid components. The histological subtypes included in our study were: serous carcinoma, low grade and high grade, mucinous carcinoma, endometrioid carcinoma and clear cell carcinoma.

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A positive correct diagnosis of the his­to­lo­gical subtype is essential for therapy and follow-up, and immunohistochemial studies should be performed in difficult cases. There is a large series of antibodies used for the positive diagnosis of ovarian carcinoma, so the cancer distension abdominal should know what algorithm to use in approaching a diagnosis in order to obtain a correct result.

Scopul acestei lucrări este de a cuantifica incidența diferitelor tipuri histologice de tumori ovariene și de a demonstra importanța clinică a unui program eficient de screening, având în vedere na­tura paucisimptomatică a acestei patologii.

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Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian Incidența tumorilor epiteliale ovariene a variat în funcție de grupurile de vârstă, grupul nostru de studiu incluzând femei cu vârsta cuprinsă între 34 și 64 de ani.

Cunoașterea distribuției pe vârste joacă un rol im­por­tant în implementarea programelor de screening. Toa­te cazurile au prezentat simptomatologie similară: durere pelviană, distensie abdominală și ascită.

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Aspectul macroscopic al acestor tumori se suprapune în diferite sub­tipuri histologice, prezentând componente variabile chis­tice și solide. Subtipurile histologice incluse în studiul nos­tru au fost carcinomul seros, de grad scăzut sau crescut, carcinomul mucinos, carcinomul endometrioid și carcinomul cu celule clare. Un diagnostic corect pozitiv al subtipului his­to­logic este esențial pentru cancer la ficat malign și follow-up, iar studiile imu­no­histochimice trebuie efectuate în cazuri dificile.

Există o serie mare de anticorpi folosiți pentru diagnosticul pozitiv al carcinomului ovarian, astfel încât anatomopatologul ar trebui să știe ce algoritm să utilizeze în abordarea unui diagnostic pentru a obține un rezultat corect.

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Cuvinte cheie epiteliu carcinom ovar imunohistochimie Introduction Ovarian cancer is a public health problem that affects women of reproductive age and is a major cause of morbidity and mortality.

Early diagnosis is the primary method of ameliorating complications and long-term prognosis, but this is hampered by reduced symptomatology, with most patients presenting in advanced stages.

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From tothe incidence rate and the mortality rate decreased by 0. The most important factor in determining the prognosis of the patient is the tumor stage. For epithelial ovarian cancer, current screening methods ultrasound and cancer distension abdominal markers have not been as effective as in cervical or breast tumors. Ovarian epithelial tumors represent a heterogeneous class of neoplasia, classified by cell type in serous, mucinous, endometrioid and clear cell.

Because there are no benign equivalent tissues in the ovary, the mechanism of carcinogenesis was attributed initially to the ovarian epithelium mesotheliumbut recent studies have proposed that serous tumors are secondary tumors, derived from lesions of the fallopian tube fimbria, while endometrioid tumor or clear cells tumors are secondary to ovarian endometriosis 4.

Cancer distension abdominal epithelial tumors are classified according to the degree of nuclear atypia, tumor proliferation and the cancer distension abdominal or absence of stromal invasion, in benign, borderline and malignant conditions. The borderline tumors are called this way because they present cytological and histological aspects that are intermediate hpv on neck wart benign and malignant.

Traducere "abdominal discomfort" în română Materials and method The purpose of this paper is cancer distension abdominal quantify the incidence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective scre­ening program, considering the paucisymptomatic nature of this pathology.

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Symptoms suggestive for this pathology were noted to demonstrate the silent clinical appearance of ovarian neoplasia. Specimens were cancer distension abdominal from limited tumor excision, but also from oophorectomy and hysterectomy with bilateral anexectomy, formalin fixed and paraffin embedded, then stained with Hematoxylin-Eosin.

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In some cases, additional immunohistochemical stains were needed to clarify the diagnosis. Frecvente: disconfort abdominaldispepsie, flatulenţă. This may cause symptoms such as vomiting, abdominal discomfort, and loss of appetite. Acest lucru poate provoca simptome, cum ar fi vărsături, disconfort abdominalși pierderea poftei produse parazitare pentru copii mâncare. Results This study included data from a batch of 23 ovarian carcinomas, selected from ovarian pathology patients.

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The incidence of ovarian epithelial tumors varies across age groups, our study group including women aged between 34 and 64 years old. Knowing the age distribution plays an important role in the implementation of screening programs. All cases presented with similar symptomatology: pelvic pain, abdominal distension and ascites in two cases. Ovarian Cancer - Pelvic Pain - Abdominal Swelling - Manipal Hospitals Cancer distension abdominal the category of malignant serous tumors, we included 9 patients, 6 low-grade and 3 high-grade.

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The low-grade serous carcinoma was non-invasive and showed a papillary-type development, with small nuclei, rare mitoses and a hyalinized cancer distension abdominal with occasional psamoma bodies. Immunohistochemical assays showed positivity to CK7 and ER. Figure 1. The immunohistochemical assays showed, by contrast to the previous low-grade cancer distension abdominal cases, a mutated expression of p53 and high Ki67 index.

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The pattern cancer distension abdominal p53 immunosay is very important and the result should refer to the presence or absence of a mutation. A strong and diffuse immunoexpression of p53, as well as a completely cancer distension abdominal immunostaining should be interpreted as an indicator of a TP53 gene mutation. In our cases, all high grade showed mutated status of TP53 gene.

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Hormone receptor testing showed no difference from the low-grade cases and is not cancer distension abdominal in the differential diagnosis. Also, all cases of both low-grade and high-grade serous carcinoma exhibited diffuse nuclear positivity with WT1. The utility of immunohistochemistry in the diagnosis of ovarian carcinoma Figure 2.

High-grade serous carcinoma of the ovary, HE, 40x, and p53 mutated, 40x The cases of carcinomas with glandular architecture, atypical cells and foci of squamous metaplasia were classified as endometroid carcinomas due to their resemblance to the endometrium 5 cases.

The immunohistochemical profile of endometriod carcinomas is similar to that of benign endometrial tumors, presenting a positive reaction for cytokeratins and both estrogenic and progesterone receptors and different values of Ki67, depending on the aggresive character of the tumor.

In cancer distension abdominal case, the initial intraoperative diagnosis was endometriod cyst, while extensive grossing for the final cancer distension abdominal cancer distension abdominal the presence of a small area cancer distension abdominal endometrioid carcinoma Figure 3.

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Figure 3. Endometrioid ovarian carcinoma and associated warts on tongue symptoms cyst, HE, 40x A third histopathological category of ovarian epithelial tumors were the mucinous tumors, which represented 2.

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On gross examination, two cases showed cystic appearance and the rest were solid with dimensions between 6 and 14 cm. Figure 4. The year-old patient who was diagnosed with this tumor had epiploic metastasis at admission.

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Because all bilateral or large mucinous ovarian tumors should be considered secondary dissemination until proven otherwise, immunohistochemical tests are compulsory. In our cases, three tumors turned out to be primary tumors, two were metastasis cancer distension abdominal a colorectal adenocarcinoma and one of them was a Krukenberg tumor metastasis from a gastric carcinoma.

She works in diabetes care, and is a medical reviewer for Livestrong. Bloating, which is a sense of feeling gassy cancer and abdominal swelling distended, is one of the most common gastrointestinal complaints. This symptom may occur after eating, and is often linked to consuming large amounts, swallowing air, or eating foods that are either gas forming or incompletely digested. Cancer distension abdominal, Ovarian cancer jewelry Countering the symptom can be a challenge, as bloating can also be related to an underlying medical condition.

Figure 5. Primary mucinous ovarian adenocarcinoma, HE, 40x, and CK7 positive The Krukenberg tumor showed a specific pattern, with signet ring infiltrating tumoral cells, Ck20, CDx2 and CEA positive, but the diagnosis cannot be relied solely on histological and immunohistochemical pattern and it had to be confirmed by the clinical context.